Winter weather has caused a closure on Interstate 25 in both directions between Las Cruces and Belen.
The New Mexico Department of Transportation said the nearly 200 mile stretch will be closed until early Tuesday.
Motorists are advised to find a nearby hotel or stay home.
Interstate 10 has also been closed in both directions from Lordsburg to Las Cruces.
A number of accidents have been reported on I-10 between Las Cruces and Deming.
There was also a multiple car pileup on I-10 at mile marker 139, east of the Las Cruces Airport.
U.S. 70 between Alamogordo and Las Cruces is also closed.
Both closures are expected to last until Tuesday morning as well.
Bad weather also caused officials to close I-40 eastbound at Louisiana NE in Albuquerque.